Journal of molecular neuroscience : MN · 2005
Monoamine oxidase a polymorphism in Brazilian patients: risk factor for late-onset Alzheimer's disease?
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Nishimura Agnes L, Guindalini Camila, Oliveira João R M, Nitrini Ricardo, Bahia Valéria S, de Brito-Marques Paulo R, Otto Paulo A, Zatz Mayana
Аннотация
Different studies have attempted to find polymorphisms involved in the serotonergic pathway that could be involved in mood disorders and late-onset Alzheimer's disease (LOAD) symptoms. Here, we compared the frequency of two polymorphisms: monoamine oxidase A (MAOA) and serotonin transporter in LOAD patients versus controls. No evidence of association was observed when these polymorphisms were compared separately; however, the combination of the MAOA allele 1+the short allele of 5-HTTLPR+ApoE-epsilon4 was significantly more frequent in patients than in controls. It reinforces the hypothesis that different genes acting together might play a role in AD susceptibility. Based on these data, we suggest replicating these studies in larger samples of LOAD patients belonging to different ethnic groups.