European journal of endocrinology · 2022
ACTH-independent production of 11-oxygenated androgens and glucocorticoids in an adrenocortical adenoma.
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Kitamura Takuya, Blinder Amy R, Nanba Kazutaka, Tsuiki Mika, Mishina Mutsuki, Okuno Hiroshi, Moriyoshi Koki, Yamazaki Yuto, Sasano Hironobu, Yoneyama Keisuke, Udager Aaron M, Rainey William E, Yasoda Akihiro, Satoh-Asahara Noriko, Tagami Tetsuya
Аннотация
Due to its rarity, biochemical and histologic characteristics of androgen and glucocorticoid co-secreting adrenocortical adenomas are largely unknown. Herein, we report a case of adrenocortical adenoma that caused marked hyperandrogenemia and mild autonomous cortisol secretion. In this study, we investigated serum steroid profiles using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and histologic characteristics of the resected tumor. LC-MS/MS revealed highly elevated levels of 11-oxygenated androgens which have not been well studied in adrenal tumors. The expression patterns of steroidogenic enzymes determined by immunohistochemistry supported the results of steroid profiling and suggested the capacity of the tumor cells to produce 11-oxygenated androgens. Measurement of 11-oxygenated steroids should facilitate a better understanding of androgen-producing adrenocortical neoplasms.