Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2011
Evaluation of allergic vesicular reaction to patch test using in vivo confocal microscopy.
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Ardigò Marco, Longo Caterina, Cristaudo Antonio, Berardesca Enzo, Pellacani Giovanni
Аннотация
BACKGROUND: Confocal microscopy has been successfully applied both in oncologic and inflammatory diseases. In particular, it has been proved as a useful tool for the in vivo detection of microscopical changes occurring in allergic reactions.
AIMS OF THE STUDY: To evaluate microscopic changes occurring in positive patch test reactions.
METHODS: Eight patients with history of allergic dermatitis and positive patch test reaction were analysed by means of confocal microscopy.
RESULTS: Confocal microscopy showed the presence of spongiotic vesicle preferentially localized around the adnexal ducts that appeared to be in the middle of the spongiotic phenomena.
CONCLUSION: Confocal microscopy offered for the first time new insight into vesicle formation and development, showing that adnexal ducts can play a role in allergic reaction.
AIMS OF THE STUDY: To evaluate microscopic changes occurring in positive patch test reactions.
METHODS: Eight patients with history of allergic dermatitis and positive patch test reaction were analysed by means of confocal microscopy.
RESULTS: Confocal microscopy showed the presence of spongiotic vesicle preferentially localized around the adnexal ducts that appeared to be in the middle of the spongiotic phenomena.
CONCLUSION: Confocal microscopy offered for the first time new insight into vesicle formation and development, showing that adnexal ducts can play a role in allergic reaction.