International ophthalmology · 2025
Clinical characteristics and antibiotic susceptibility patterns of bacterial keratitis in the South of Vietnam.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
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Nguyen Thi Truc Mai, Tran Ngoc Huy, Nguyen Huynh Phuc, Fung Simon, Pham Nguyen Huan, Lam Minh Vinh, Vu Thi Viet Thu, Duong Nguyen Viet Huong
Аннотация
BACKGROUND: Infectious keratitis is a major cause of corneal blindness, with bacterial keratitis particularly prevalent in tropical, agriculture-dominant regions such as Southern Vietnam.
PURPOSES: To identify the demographic characteristics, risk factors, clinical features, and antibiotic susceptibility patterns of bacteria isolated from patients with corneal ulceration.
METHODS: A case series was conducted involving patients who presented to the Cornea Department of Ho Chi Minh City Eye Hospital between November 2020 and October 2021.
RESULTS: A total of ninety-nine cases of bacterial keratitis were documented. The mean age of the patients was 48.2 ± 15.3 years. Most participants were male, and the majority were cultivators (30.3%). Meibomian gland dysfunction was the most frequent predisposing factor (57.6%), followed by ocular trauma (52.5%) and diabetes mellitus (16.2%). The mean duration from symptom onset to presentation was 4.1 ± 3.1 days; however, patients with Pseudomonas aeruginosa keratitis presented significantly earlier (2.8 ± 1.6 days) than those with other bacterial infections. The most commonly isolated organisms were coagulase-negative Staphylococcus (57.6%) and Pseudomonas aeruginosa (21.2%). Staphylococcus spp. keratitis was significantly associated with peripheral infiltration, shallow stromal involvement, and absence of hypopyon. In contrast, Pseudomonas aeruginosa keratitis was strongly associated with eyelid edema, conjunctival edema, central infiltration, deep stromal involvement, stromal melting, ring infiltrate, retrocorneal plaque, hypopyon > 1 mm, and fibrin formation in the anterior chamber. The majority of coagulase-negative Staphylococcus isolates were susceptible to vancomycin (90-100%). Pseudomonas aeruginosa isolates were highly susceptible to tobramycin (100%) and levofloxacin (95.0%), whereas none were susceptible to moxifloxacin. The proportions of multidrug-resistant isolates among coagulase-negative Staphylococcus and Pseudomonas aeruginosa were 68.4% and 85.7%, respectively.
CONCLUSION: Multidrug-resistant strains among coagulase-negative Staphylococcus and Pseudomonas aeruginosa were notably prevalent. Our study provides valuable insights into the clinical and microbiological patterns of bacterial keratitis, which guide antibiotic selection and management.
PURPOSES: To identify the demographic characteristics, risk factors, clinical features, and antibiotic susceptibility patterns of bacteria isolated from patients with corneal ulceration.
METHODS: A case series was conducted involving patients who presented to the Cornea Department of Ho Chi Minh City Eye Hospital between November 2020 and October 2021.
RESULTS: A total of ninety-nine cases of bacterial keratitis were documented. The mean age of the patients was 48.2 ± 15.3 years. Most participants were male, and the majority were cultivators (30.3%). Meibomian gland dysfunction was the most frequent predisposing factor (57.6%), followed by ocular trauma (52.5%) and diabetes mellitus (16.2%). The mean duration from symptom onset to presentation was 4.1 ± 3.1 days; however, patients with Pseudomonas aeruginosa keratitis presented significantly earlier (2.8 ± 1.6 days) than those with other bacterial infections. The most commonly isolated organisms were coagulase-negative Staphylococcus (57.6%) and Pseudomonas aeruginosa (21.2%). Staphylococcus spp. keratitis was significantly associated with peripheral infiltration, shallow stromal involvement, and absence of hypopyon. In contrast, Pseudomonas aeruginosa keratitis was strongly associated with eyelid edema, conjunctival edema, central infiltration, deep stromal involvement, stromal melting, ring infiltrate, retrocorneal plaque, hypopyon > 1 mm, and fibrin formation in the anterior chamber. The majority of coagulase-negative Staphylococcus isolates were susceptible to vancomycin (90-100%). Pseudomonas aeruginosa isolates were highly susceptible to tobramycin (100%) and levofloxacin (95.0%), whereas none were susceptible to moxifloxacin. The proportions of multidrug-resistant isolates among coagulase-negative Staphylococcus and Pseudomonas aeruginosa were 68.4% and 85.7%, respectively.
CONCLUSION: Multidrug-resistant strains among coagulase-negative Staphylococcus and Pseudomonas aeruginosa were notably prevalent. Our study provides valuable insights into the clinical and microbiological patterns of bacterial keratitis, which guide antibiotic selection and management.