Double Layered 9-mm Dehydrated Amniotic Membrane Disc in Ocular Surface Disorders: A Case Series.

OBJECTIVE

To report the indications and outcomes associated with a double layered dehydrated amniotic membrane (AM) disc in managing ocular surface disorders.

METHODS

A retrospective chart review was conducted of all patients treated with a double layered 9-mm dehydrated AM at a tertiary care clinic from July 2022 to November 2023. Primary outcomes included changes in uncorrected visual acuity (UCVA) from baseline to first and last follow-up. Secondary outcomes included changes in clinical signs and presence of complications.

RESULTS

Ten cases were included (7 male, 70.0%), median age 50 years (interquartile ranges [IQR] 40-69), with median follow-up of 12.9 months (IQR 8.1-20.4). Indications included limbal stem cell deficiency (n=5), persistent epithelial defect (n=4), and aphakic bullous keratopathy (n=1). All patients showed clinical improvement, and the membrane was successfully integrated in nine eyes (90.0%) at first follow-up. Mean UCVA improved from 1.69 ± 0.62 logMAR at baseline to 1.22 ± 0.69 logMAR at first follow-up ( P =0.002) and to 0.98 ± 0.70 logMAR at last follow-up ( P =0.001). No complications occurred over the duration of follow-up.

CONCLUSIONS

The double layered dehydrated AM disc was associated with significant improvements in clinical signs and visual acuity, supporting its use as an effective in-office treatment for selected cases.