Journal of visualized experiments : JoVE · 2024
Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice.
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He Jipei, Li Heng, Dai Xiaojiang, Xie Zhengyong, Song Zhigao, Chen Xi, Huang Hongyan, Ding Yunfa, Qi Tengfei, Liu Qing, Zhang Hongbin, Wu Liangping
Аннотация
The prevalence of obesity and type 2 diabetes is a serious global health concern. Obesity is a major pathogenic factor in type 2 diabetes, cardiovascular disease, and some cancers. Bariatric surgery offers a long-term and effective treatment option for both obesity and diabetes. Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are widely recognized as the most popular bariatric surgeries. Additionally, several exploratory bariatric surgeries have demonstrated promising therapeutic effects. Duodenal-jejunal bypass (DJB), specifically tailored for diabetics with low body mass index, has shown beneficial metabolic outcomes. However, its weight-independent metabolic benefits are not fully understood due to limited animal models. In this article, we describe the optimized care protocols and surgical techniques for performing DJB surgery in diet-induced obese (DIO) diabetic mice. Using a mouse model contributes to a better understanding of the nature of changes induced by DJB surgery while facilitating related clinical practice.