Stem cell repair of striatal ischemia.

Stem cell-based approaches have promising prospects as new treatments to repair the stroke-damaged brain and promote efficient functional recovery. Studies in animal models of stroke have shown that transplantation of neural stem/progenitor cells (NSPCs) isolated from different sources can improve function not only by replacing dead neurons but also by trophic actions, modulation of inflammation, promotion of angiogenesis, and neuroprotection. Endogenous NSPCs produce new neurons following stroke and are also potential therapeutic targets. Joint efforts of basic researchers and clinicians are needed to develop safe and reproducible NSPC sources, test them in relevant animal models of stroke, and optimize the recovery of impaired functions.