Journal of pharmacy & bioallied sciences · 2025
Altered Bone Geometry and Quality in Type 2 Diabetes Mellitus: Insights from Peripheral Quantitative Computed Tomography in an Indian Cohort.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Khadilkar Anuradha V, Divate Uma, Satale Vishwajit, Gill Satyajit S, Muralidharan Shrikanth
Аннотация
BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is increasingly recognized as a risk factor for skeletal fragility, independent of bone mineral density (BMD).
OBJECTIVE: This prospective, cross-sectional case-control study investigated bone geometry using peripheral quantitative computed tomography (pQCT) in 100 patients with T2DM.
METHODOLOGY: 100 cases of Type 2 DM and healthy cohorts were compared for bone geometry at a tertiary care hospital.
RESULTS: Trabecular density was notably reduced in men, while both periosteal and endosteal circumferences were significantly diminished in both sexes, suggesting cortical thinning and compromised bone geometry.
CONCLUSION: The findings suggest that pQCT provides valuable insights into microarchitectural deficits, explaining the increased fracture risk in T2DM.
OBJECTIVE: This prospective, cross-sectional case-control study investigated bone geometry using peripheral quantitative computed tomography (pQCT) in 100 patients with T2DM.
METHODOLOGY: 100 cases of Type 2 DM and healthy cohorts were compared for bone geometry at a tertiary care hospital.
RESULTS: Trabecular density was notably reduced in men, while both periosteal and endosteal circumferences were significantly diminished in both sexes, suggesting cortical thinning and compromised bone geometry.
CONCLUSION: The findings suggest that pQCT provides valuable insights into microarchitectural deficits, explaining the increased fracture risk in T2DM.