Altered Bone Geometry and Quality in Type 2 Diabetes Mellitus: Insights from Peripheral Quantitative Computed Tomography in an Indian Cohort.

BACKGROUND

Type 2 Diabetes Mellitus (T2DM) is increasingly recognized as a risk factor for skeletal fragility, independent of bone mineral density (BMD).

OBJECTIVE

This prospective, cross-sectional case-control study investigated bone geometry using peripheral quantitative computed tomography (pQCT) in 100 patients with T2DM.

METHODOLOGY: 100 cases of Type 2 DM and healthy cohorts were compared for bone geometry at a tertiary care hospital.

RESULTS

Trabecular density was notably reduced in men, while both periosteal and endosteal circumferences were significantly diminished in both sexes, suggesting cortical thinning and compromised bone geometry.

CONCLUSION

The findings suggest that pQCT provides valuable insights into microarchitectural deficits, explaining the increased fracture risk in T2DM.