The role of cellular development and cell death in neurochemical organization and integrative brain functions--normal and pathological.

In terms of systemic aspects of common molecular mechanisms of development, important part of which is the process of cellular death and integrative activity of nervous system, a complex clinical-experimental study of effects of various neurotrophic and apoptotic factors (proteins S100b, HLDF, brain lectins CSL and R1) on learning and memory and ischemic stroke was performed. Data concerning specific and heterochronic participation of these factors in neurochemical mechanisms of learning and memory in mechanisms of ischemic stroke formation were established. Changes of examined factors and their antibodies as well as the dynamics of changes in sera and cerebrospinal fluid can be considered as prognostic markers of ischemic stroke and efficiency of therapy.