[Evaluation of insulin sensitivity in diabetes using the euglycemic hyperinsulinemic clamp method].

Assessment of peripheral insulin sensitivity using artificial endocrine pancreas was done in 15 diabetics (6 with insulin dependent diabetes mellitus and 9 with non-insulin dependent diabetes mellitus) and in 10 healthy controls, matched for sex, age and body mass index. Insulin sensitivity-RC was expressed in mg of utilised glucose/kg body weight in minute. Significantly lower insulin sensitivity was found in non-insulin dependent diabetes mellitus (RC = 2.30 +/- 1.37) compared to insulin dependent group (RC = 5.88 +/- 2.89) and control group (RC = 4.93 +/- 1.96). There was no significant change in insulin sensitivity between insulin dependent diabetics and controls (p greater than 0.05). It is concluded that investigations of this kind could be used in search for pathogenetic mechanism of insulin resistance in some types of diabetes mellitus on one side, and on the other side that euglycemic clamp technique could be used for the assessment of the effects of some therapeutical measures on peripheral insulin sensitivity.