European psychiatry : the journal of the Association of European Psychiatrists · 2022
MICEmi: A method to identify cognitive endophenotypes of mental illnesses.
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Correa-Ghisays Patricia, Vicent Sánchez-Ortí Joan, Balanzá-Martínez Vicent, Fuentes-Durá Inmaculada, Martinez-Aran Anabel, Ruiz-Bolo Lara, Correa-Estrada Paulina, Ruiz-Ruiz Juan Carlos, Selva-Vera Gabriel, Vila-Francés Joan, Macias Saint-Gerons Diego, San-Martín Constanza, Ayesa-Arriola Rosa, Tabarés-Seisdedos Rafael
Аннотация
BACKGROUND: Characterizing neurocognitive endophenotypes of mental illnesses (MIs) could be useful for identifying at-risk individuals, increasing early diagnosis, improving disease subtyping, and proposing therapeutic strategies to reduce the negative effects of the symptoms, in addition to serving as a scientific basis to unravel the physiopathology of the disease. However, a standardized algorithm to determine cognitive endophenotypes has not yet been developed. The main objective of this study was to present a method for the identification of endophenotypes in MI research.
METHODS: For this purpose, a 14-expert working group used a scoping review methodology and designed a method that includes a scoring template with five criteria and indicators, a strategy for their verification, and a decision tree.
CONCLUSIONS: This work is ongoing since it is necessary to obtain external validation of the applicability of the method in future research.
METHODS: For this purpose, a 14-expert working group used a scoping review methodology and designed a method that includes a scoring template with five criteria and indicators, a strategy for their verification, and a decision tree.
CONCLUSIONS: This work is ongoing since it is necessary to obtain external validation of the applicability of the method in future research.