Revista peruana de medicina experimental y salud publica · 2018
[Connection Between Genetic Polymorphism of Interleukin -1Beta With Chronic Periodontitis in Peruvian Adults].
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Reyes-Mandujano Ivonne F, Olivera-García José E, Taboada-Vega Manuel, Galvan-Sanchez Patricia, Azcarza-Acuña Amilcar, M Yactayo-Flores Aldo, Zuñiga-Ccoicca Luis A, Leiva-Pachas Evelyn V, Paccori-García Efraín
Аннотация
OBJECTIVES: . To determine the connection between polymorphism IL-1B C(+3953/4)T and chronic periodontitis in adults.
MATERIALS AND METHODS: . Case and control study. Individuals between 18 and 64 years of age were included; they were recruited through healthcare campaigns carried out in 2012 in different areas of the city of Lima with similar socio-economic characteristics. Dentists specialized in periodontics performed the diagnosis of the periodontal state of participants; genotyping was made through the PCR-RFLP technique. The data were analyzed by logistic regression.
RESULTS: . The factors associated with chronic periodontitis were: age over 46 years (OR: 7.50, CI 95%: 1.85-6.37), higher education level achieved (OR: 0.43, CI 95%: 0.27-0.98), the presence of allele 2 in the polymorphism of IL-1B. The positive genotype (2-2) was associated with the presence of chronic periodontitis (OR: 2.06, CI 95%: 1.01-4.21).
CONCLUSIONS: . The presence of allele 2 in the polymorphism of IL-1B and the positive genotype (2-2) confers greater risk for the development of chronic periodontitis in the population of Peruvian adults under study.
MATERIALS AND METHODS: . Case and control study. Individuals between 18 and 64 years of age were included; they were recruited through healthcare campaigns carried out in 2012 in different areas of the city of Lima with similar socio-economic characteristics. Dentists specialized in periodontics performed the diagnosis of the periodontal state of participants; genotyping was made through the PCR-RFLP technique. The data were analyzed by logistic regression.
RESULTS: . The factors associated with chronic periodontitis were: age over 46 years (OR: 7.50, CI 95%: 1.85-6.37), higher education level achieved (OR: 0.43, CI 95%: 0.27-0.98), the presence of allele 2 in the polymorphism of IL-1B. The positive genotype (2-2) was associated with the presence of chronic periodontitis (OR: 2.06, CI 95%: 1.01-4.21).
CONCLUSIONS: . The presence of allele 2 in the polymorphism of IL-1B and the positive genotype (2-2) confers greater risk for the development of chronic periodontitis in the population of Peruvian adults under study.