Contact dermatitis · 2025
Trends in Contact Allergy to Chromium Following the 2015 European Union Leather Regulation.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kursawe Larsen Christoffer, Jensen Mikkel Bak, Isufi Daniel, Zachariae Claus, Johansen Jeanne Duus, Schwensen Jakob F B
Аннотация
BACKGROUND: Chromium (Cr) may cause contact allergy with leather being the most important exposure. To reduce contact allergy to Cr, the European Union (EU) implemented a regulation in 2015 limiting the maximum amount of hexavalent Cr in leather that comes into contact with the skin to 3 mg/kg.
OBJECTIVES: To investigate prevalences, trends, and clinical and demographic characteristics of patients with contact allergy to Cr following the EU regulation.
METHODS: A cross-sectional study was conducted. Patients aged ≥ 18 years, who were consecutively patch tested with potassium dichromate 0.5% in petrolatum at Gentofte hospital, Denmark, from 2016 to 2024, were included.
RESULTS: A total of 4830 patients were included. The overall prevalence of contact allergy to Cr was 2.1% with stable trends across test years. Contact allergy to Cr was associated with hand, leg and foot dermatitis, and age > 40 years. The most frequent exposure was leather shoes.
CONCLUSION: Contact allergy to Cr was found to be frequent and stable. The 2015 EU regulation on the content of Cr in leather does not yet appear to significantly reduce the prevalence of contact allergy to Cr, when compared with previous Gentofte data from 2006 to 2009 (2.3%, p = 0.65) and from 2010 to 2013 (1.9%, p = 0.41).
OBJECTIVES: To investigate prevalences, trends, and clinical and demographic characteristics of patients with contact allergy to Cr following the EU regulation.
METHODS: A cross-sectional study was conducted. Patients aged ≥ 18 years, who were consecutively patch tested with potassium dichromate 0.5% in petrolatum at Gentofte hospital, Denmark, from 2016 to 2024, were included.
RESULTS: A total of 4830 patients were included. The overall prevalence of contact allergy to Cr was 2.1% with stable trends across test years. Contact allergy to Cr was associated with hand, leg and foot dermatitis, and age > 40 years. The most frequent exposure was leather shoes.
CONCLUSION: Contact allergy to Cr was found to be frequent and stable. The 2015 EU regulation on the content of Cr in leather does not yet appear to significantly reduce the prevalence of contact allergy to Cr, when compared with previous Gentofte data from 2006 to 2009 (2.3%, p = 0.65) and from 2010 to 2013 (1.9%, p = 0.41).