European eating disorders review : the journal of the Eating Disorders Association · 2017
Daily Changes in Composition and Diversity of the Intestinal Microbiota in Patients with Anorexia Nervosa: A Series of Three Cases.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kleiman Susan C, Glenny Elaine M, Bulik-Sullivan Emily C, Huh Eun Young, Tsilimigras Matthew C B, Fodor Anthony A, Bulik Cynthia M, Carroll Ian M
Аннотация
Anorexia nervosa, a severe psychiatric illness, is associated with an intestinal microbial dysbiosis. Individual microbial signatures dominate in healthy samples, even over time and under controlled conditions, but whether microbial markers of the disorder overcome inter-individual variation during the acute stage of illness or renourishment is unknown. We characterized daily changes in the intestinal microbiota in three acutely ill patients with anorexia nervosa over the entire course of hospital-based renourishment and found significant, patient-specific changes in microbial composition and diversity. This preliminary case series suggests that even in a state of pathology, individual microbial signatures persist in accounting for the majority of intestinal microbial variation. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.