The Journal of dermatological treatment · 2010
Combination of azelaic acid 5% and erythromycin 2% in the treatment of acne vulgaris.
Сравнительное исследованиеСтатьяМногоцентровое исследованиеРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Pazoki-Toroudi Hamidreza, Nassiri-Kashani Mansour, Tabatabaie Hossein, Ajami Marjan, Habibey Rouhollah, Shizarpour Mohammad, Babakoohi Shahab, Rahshenas Makan, Firooz Alireza
Аннотация
INTRODUCTION: Acne vulgaris is a common problem, particularly among adolescents, which is usually resistant to monotherapy. We evaluated the efficacy and safety of a combination of azelaic acid (AA) 5% and erythromycin 2% gel (AzE) compared with AA 20% or erythromycin 2% gels in facial acne vulgaris.
METHODS: We conducted a 12-week, multicenter, randomized double-blind study on 147 patients with mild-to-moderate acne vulgaris. Four treatment group were determined (placebo, erythromycin, AA and AzE) and followed in 4-week intervals for 12 weeks, except the placebo group which was changed to routine treatment after 4 weeks.
RESULTS: The combination of AA 5% and erythromycin 2% gel significantly reduced the number of papules, pustules and comedones compared with placebo (p < 0.001), erythromycin 2% (p < 0.01) or AA 20% (p < 0.05). The incidence of adverse effects observed in patients treated with AzE (27%) was less than that with erythromycin 2% (54%) and AA 20% (45%).
CONCLUSIONS: The combination of AA 5% and erythromycin 2% produced more potent therapeutic effects in comparison with erythromycin 2% or AA 20% alone, and with fewer side effects.
METHODS: We conducted a 12-week, multicenter, randomized double-blind study on 147 patients with mild-to-moderate acne vulgaris. Four treatment group were determined (placebo, erythromycin, AA and AzE) and followed in 4-week intervals for 12 weeks, except the placebo group which was changed to routine treatment after 4 weeks.
RESULTS: The combination of AA 5% and erythromycin 2% gel significantly reduced the number of papules, pustules and comedones compared with placebo (p < 0.001), erythromycin 2% (p < 0.01) or AA 20% (p < 0.05). The incidence of adverse effects observed in patients treated with AzE (27%) was less than that with erythromycin 2% (54%) and AA 20% (45%).
CONCLUSIONS: The combination of AA 5% and erythromycin 2% produced more potent therapeutic effects in comparison with erythromycin 2% or AA 20% alone, and with fewer side effects.
Предметные рубрики MeSH
Acne VulgarisAdministration, CutaneousAdolescentAdultAnalysis of VarianceAnti-Bacterial AgentsDermatologic AgentsDicarboxylic AcidsDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleDrug Therapy, CombinationErythromycinFemaleFollow-Up StudiesHumansMaleProbabilityReference ValuesRisk AssessmentSeverity of Illness IndexStatistics, NonparametricTreatment OutcomeYoung Adult