Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2009
A comparative study of topical 5-aminolevulinic acid incubation times in photodynamic therapy with intense pulsed light for the treatment of inflammatory acne.
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Oh Sang Ho, Ryu Dong Jin, Han Eun Chun, Lee Kwang Hoon, Lee Ju Hee
Аннотация
BACKGROUND: Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is used for effective treatment of facial acne vulgaris.
OBJECTIVES: To determine which of two different incubation times (30 minutes and 3 hours) is more effective in PDT with intense pulsed light (IPL) for acne vulgaris.
METHODS & MATERIALS: Twenty Korean subjects with moderate to severe acne were enrolled for a randomized, half-facial treatment study. Three sessions with short incubation with ALA plus IPL (30 minutes, n=9) or long incubation with ALA plus IPL (3 hours, n=11) on one side of the face and IPL alone on the other side were performed at 1-month intervals.
RESULTS: All subjects showed improvement in inflammatory acne lesions after three sessions of ALA-PDT or IPL alone (p<.001 in all groups). The degree of improvement in inflammatory acne lesions was greater in the long incubation time group than the short incubation time group or the IPL-alone group, although the mean reduction of inflammatory acne lesions was statistically different only between the long incubation group and the IPL-only group (p=.01). There were no statistical differences between the short incubation group and IPL-alone group. All three groups had decreased sebum secretion after three sessions (p<.001 in all groups), but the differences between groups were not statistically significant. Only transient erythema and mild edema were reported for all treatment groups.
CONCLUSION: PDT with a long ALA incubation time might be more adequate for a pronounced outcome with inflammatory acne.
OBJECTIVES: To determine which of two different incubation times (30 minutes and 3 hours) is more effective in PDT with intense pulsed light (IPL) for acne vulgaris.
METHODS & MATERIALS: Twenty Korean subjects with moderate to severe acne were enrolled for a randomized, half-facial treatment study. Three sessions with short incubation with ALA plus IPL (30 minutes, n=9) or long incubation with ALA plus IPL (3 hours, n=11) on one side of the face and IPL alone on the other side were performed at 1-month intervals.
RESULTS: All subjects showed improvement in inflammatory acne lesions after three sessions of ALA-PDT or IPL alone (p<.001 in all groups). The degree of improvement in inflammatory acne lesions was greater in the long incubation time group than the short incubation time group or the IPL-alone group, although the mean reduction of inflammatory acne lesions was statistically different only between the long incubation group and the IPL-only group (p=.01). There were no statistical differences between the short incubation group and IPL-alone group. All three groups had decreased sebum secretion after three sessions (p<.001 in all groups), but the differences between groups were not statistically significant. Only transient erythema and mild edema were reported for all treatment groups.
CONCLUSION: PDT with a long ALA incubation time might be more adequate for a pronounced outcome with inflammatory acne.