Journal of clinical periodontology · 2015
Periodontitis and retinal microcirculation in the Atherosclerosis Risk in Communities study.
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Boillot Adrien, Bouchard Philippe, Moss Kevin, Offenbacher Steven, Czernichow Sébastien
Аннотация
AIM: The aim of this cross-sectional study is to explore if periodontitis is associated with alterations of the retinal microcirculation, a predictive marker of cardiovascular events.
MATERIAL AND METHODS: Of 457 subjects aged 52 years and more from the ARIC cohort were included. Retinal vascular diameters were measured and summarized as central retinal arteriolar/venular equivalents (CRAE/CRVE). Periodontitis was determined by using the CDC/AAP definition. Multivariable linear regression models were used to estimate the relationships between CRAE, CRVE and periodontitis.
RESULTS: No association was found between CRAE and periodontal status. However, CRVE and severe periodontitis were positively and significantly associated. Mean CRVE (±SD) was 187.0 ± 17.2 μm in the health-gingivitis group, and, respectively, 188.5 ± 16.3 μm (p = 0.39) and 191.6 ± 16.8 μm (p = 0.04) in moderate and severe periodontitis groups, after adjustment for a propensity score based on confounders. Results were consistent when analyses were restricted to participants with diabetes mellitus (n = 66), but not diabetes-free subjects.
CONCLUSIONS: Severe periodontitis is associated with larger retinal venular diameter in patients with type 2 diabetes. Further studies are needed to explore the impact of diabetes mellitus on the association between periodontitis and retinal microcirculation.
MATERIAL AND METHODS: Of 457 subjects aged 52 years and more from the ARIC cohort were included. Retinal vascular diameters were measured and summarized as central retinal arteriolar/venular equivalents (CRAE/CRVE). Periodontitis was determined by using the CDC/AAP definition. Multivariable linear regression models were used to estimate the relationships between CRAE, CRVE and periodontitis.
RESULTS: No association was found between CRAE and periodontal status. However, CRVE and severe periodontitis were positively and significantly associated. Mean CRVE (±SD) was 187.0 ± 17.2 μm in the health-gingivitis group, and, respectively, 188.5 ± 16.3 μm (p = 0.39) and 191.6 ± 16.8 μm (p = 0.04) in moderate and severe periodontitis groups, after adjustment for a propensity score based on confounders. Results were consistent when analyses were restricted to participants with diabetes mellitus (n = 66), but not diabetes-free subjects.
CONCLUSIONS: Severe periodontitis is associated with larger retinal venular diameter in patients with type 2 diabetes. Further studies are needed to explore the impact of diabetes mellitus on the association between periodontitis and retinal microcirculation.
Предметные рубрики MeSH
Age FactorsAgedAlcohol DrinkingAtherosclerosisCohort StudiesCross-Sectional StudiesDiabetes Mellitus, Type 2Educational StatusFemaleGingival RecessionHumansLongitudinal StudiesMacula LuteaMaleMicrocirculationMiddle AgedOptic DiskPeriodontal Attachment LossPeriodontal PocketPeriodontitisRetinal ArteryRetinal VeinRetinal VesselsSex FactorsSmoking