PloS one · 2026
Effects of hearing intervention on physical function: A secondary analysis of the ACHIEVE study.
СтатьяМногоцентровое исследованиеРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Deal Jennifer A, Zhang Wuyang, Jiang Kening, Huang Alison, Pike James Russell, Arnold Michelle, Burgard Sheila, Chen Ziheng Sally, Chisolm Theresa, Couper David, Goman Adele M, Glynn Nancy W, Gmelin Theresa, Gravens-Mueller Lisa, Hayden Kathleen M, Mitchell Christine M, Pankow James S, Reed Nicholas S, Sanchez Victoria, Schrack Jennifer A, Sullivan Kevin, Lin Frank R, Coresh Josef, ACHIEVE Collaborative Research Group
Аннотация
OBJECTIVE: We tested the effect of the hearing intervention vs. health education control (1:1 randomization) on 3-year physical function decline, a secondary analysis of the ACHIEVE randomized trial (ClinicalTrials.gov Identifier: NCT03243422).
METHODS: Pre-specified outcomes included the Short Physical Performance Battery (SPPB) [total score and components] and grip strength. Intervention effects were modeled using linear mixed models following a pre-specified statistical analysis plan.
RESULTS: In 956 participants (mean 76.3 years, 53% female, 12% Black race), hearing intervention did not impact change in SPPB (difference comparing intervention to control = 0.00 standard deviation [SD] units, 95% confidence interval [CI]:-0.14, 0.14) or grip strength (difference = 0.01 SD, 95% CI: -0.06, 0.08). However, treatment effects varied by recruitment cohort; although findings were not statistically significant, they suggest a clinically meaningful benefit (slower decline) in participants with faster rates of cognitive decline.
CONCLUSIONS: These secondary results have direct relevance for inclusion in systematic reviews and meta-analyses. Future research should be designed to test whether hearing intervention can reduce short-term declines in physical function, particularly among those experiencing cognitive decline. Continuing follow-up of the ACHIEVE study participants will yield insights into longer-term (>3 years) effects of intervention.
METHODS: Pre-specified outcomes included the Short Physical Performance Battery (SPPB) [total score and components] and grip strength. Intervention effects were modeled using linear mixed models following a pre-specified statistical analysis plan.
RESULTS: In 956 participants (mean 76.3 years, 53% female, 12% Black race), hearing intervention did not impact change in SPPB (difference comparing intervention to control = 0.00 standard deviation [SD] units, 95% confidence interval [CI]:-0.14, 0.14) or grip strength (difference = 0.01 SD, 95% CI: -0.06, 0.08). However, treatment effects varied by recruitment cohort; although findings were not statistically significant, they suggest a clinically meaningful benefit (slower decline) in participants with faster rates of cognitive decline.
CONCLUSIONS: These secondary results have direct relevance for inclusion in systematic reviews and meta-analyses. Future research should be designed to test whether hearing intervention can reduce short-term declines in physical function, particularly among those experiencing cognitive decline. Continuing follow-up of the ACHIEVE study participants will yield insights into longer-term (>3 years) effects of intervention.