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DOI 10.1126/sciimmunol.abq5204

Медицинская библиотека · Science immunology · 2023

Human IL-23 is essential for IFN-γ-dependent immunity to mycobacteria.

Philippot Quentin, Ogishi Masato, Bohlen Jonathan, Puchan Julia, Arias Andrés Augusto, Nguyen Tina, Martin-Fernandez Marta, Conil Clement, Rinchai Darawan, Momenilandi Mana, Mahdaviani Seyed Alireza, Keramatipour Mohammad, Rosain Jérémie, Yang Rui, Khan Taushif, Neehus Anna-Lena, Materna Marie, Han Ji Eun, Peel Jessica, Mele Federico, Weisshaar Marc, Jovic Sandra, Bastard Paul, Lévy Romain, Le Voyer Tom, Zhang Peng, Maglorius Renkilaraj Majistor Raj Luxman, Arango-Franco Carlos A, Pelham Simon, Seeleuthner Yoann, Pochon Mathieu, Ata Manar Mahmoud Ahmad, Al Ali Fatima, Migaud Mélanie, Soudée Camille, Kochetkov Tatiana, Molitor Anne, Carapito Raphael, Bahram Seiamak, Boisson Bertrand, Fieschi Claire, Mansouri Davood, Marr Nico, Okada Satoshi, Shahrooei Mohammad, Parvaneh Nima, Chavoshzadeh Zahra, Cobat Aurélie, Bogunovic Dusan, Abel Laurent, Tangye Stuart G, Ma Cindy S, Béziat Vivien, Sallusto Federica, Boisson-Dupuis Stéphanie, Bustamante Jacinta, Casanova Jean-Laurent, Puel Anne

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less commonly, chronic mucocutaneous candidiasis (CMC) due to impaired IL-17A/F production. We report six patients from four kindreds with AR IL-23R deficiency. These patients are homozygous for one of four different loss-of-function IL23R variants. All six patients have a history of MSMD, but only two suffered from CMC. We show that IL-23 induces IL-17A only in MAIT cells, possibly contributing to the incomplete penetrance of CMC in patients unresponsive to IL-23. By contrast, IL-23 is required for both baseline and Mycobacterium-inducible IFN-γ immunity in both Vδ2+ γδ T and MAIT cells, probably contributing to the higher penetrance of MSMD in these patients. Human IL-23 appears to contribute to IL-17A/F-dependent immunity to Candida in a single lymphocyte subset but is required for IFN-γ-dependent immunity to Mycobacterium in at least two lymphocyte subsets.

Для цитирования: Philippot Quentin, Ogishi Masato, Bohlen Jonathan, Puchan Julia, Arias Andrés Augusto, Nguyen Tina, Martin-Fernandez Marta, Conil Clement, Rinchai Darawan, Momenilandi Mana, Mahdaviani Seyed Alireza, Keramatipour Mohammad, Rosain Jérémie, Yang Rui, Khan Taushif, Neehus Anna-Lena, Materna Marie, Han Ji Eun, Peel Jessica, Mele Federico, Weisshaar Marc, Jovic Sandra, Bastard Paul, Lévy Romain, Le Voyer Tom, Zhang Peng, Maglorius Renkilaraj Majistor Raj Luxman, Arango-Franco Carlos A, Pelham Simon, Seeleuthner Yoann, Pochon Mathieu, Ata Manar Mahmoud Ahmad, Al Ali Fatima, Migaud Mélanie, Soudée Camille, Kochetkov Tatiana, Molitor Anne, Carapito Raphael, Bahram Seiamak, Boisson Bertrand, Fieschi Claire, Mansouri Davood, Marr Nico, Okada Satoshi, Shahrooei Mohammad, Parvaneh Nima, Chavoshzadeh Zahra, Cobat Aurélie, Bogunovic Dusan, Abel Laurent, Tangye Stuart G, Ma Cindy S, Béziat Vivien, Sallusto Federica, Boisson-Dupuis Stéphanie, Bustamante Jacinta, Casanova Jean-Laurent, Puel Anne. Human IL-23 is essential for IFN-γ-dependent immunity to mycobacteria.. Science immunology. 2023. DOI: 10.1126/sciimmunol.abq5204.

Предметные рубрики MeSH

HumansGenetic Predisposition to DiseaseInterferon-gammaInterleukin-17Interleukin-23MycobacteriumMycobacterium Infections
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