Oral histoplasmosis: diagnostic complication and treatment.

Intraoral histoplasmosis is difficult to diagnose, both because the clinician fails to be aware of it and because the lesion has clinical similarities to other disease entities, creating a misleading clinical impression. Effective communication between clinician and pathologist is essential, if one is to arrive at an accurate diagnosis and provide the best treatment. A new antimycotic agent, ketoconazole, is now available for oral administration. Studies indicate that it has major therapeutic advantages and significantly lower toxicity than comparable antimycotic agents.