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DOI 10.2217/fon.15.302

Медицинская библиотека · Future oncology (London, England) · 2016

Clinical outcomes in octogenarians treated with docetaxel as first-line chemotherapy for castration-resistant prostate cancer.

Veccia Antonello, Caffo Orazio, De Giorgi Ugo, Di Lorenzo Giuseppe, Ortega Cinzia, Scognamiglio Florinda, Aieta Michele, Facchini Gaetano, Mansueto Giovanni, Mattioli Rodolfo, Procopio Giuseppe, Zagonel Vittorina, D'Angelo Alessandro, Spizzo Gilbert, Bortolus Roberto, Donini Maddalena, Lo Re Giovanni, Massari Francesco, Vicario Giovanni, Zucali Paolo A, Alesini Daniele, Bonetti Andrea, Mucciarini Claudia, Nicodemo Maurizio, Berruti Alfredo, Fratino Lucia, Lodde Michele, Messina Caterina, Perin Alessandra, Santini Daniele, Sava Teodoro, Tucci Marcello, Basso Umberto, Maines Francesca, Burgio Luca S, Galligioni Enzo

СтатьяМногоцентровое исследованиеПеревод пока не подготовлен

Аннотация

AIM: To assess clinical outcomes in octogenarians treated with docetaxel (DOC) for metastatic castration-resistant prostate cancer.

PATIENTS &

METHODS

The multicenter retrospective study was based on a review of the pre- and post-DOC clinical history, DOC treatment and outcomes.

RESULTS

We reviewed the records of 123 patients (median age: 82 years) who received DOC every 3 weeks or weekly, without significant grade 3-4 toxicities. Median progression-free survival was 7 months; median overall survival from the start of DOC was 20 months, but post-progression treatments significantly prolonged overall survival.

CONCLUSION

The findings of this study suggest that toxicity is acceptable, survival is independent of patient's age and survival can be significantly prolonged by the use of new agents.

Для цитирования: Veccia Antonello, Caffo Orazio, De Giorgi Ugo, Di Lorenzo Giuseppe, Ortega Cinzia, Scognamiglio Florinda, Aieta Michele, Facchini Gaetano, Mansueto Giovanni, Mattioli Rodolfo, Procopio Giuseppe, Zagonel Vittorina, D'Angelo Alessandro, Spizzo Gilbert, Bortolus Roberto, Donini Maddalena, Lo Re Giovanni, Massari Francesco, Vicario Giovanni, Zucali Paolo A, Alesini Daniele, Bonetti Andrea, Mucciarini Claudia, Nicodemo Maurizio, Berruti Alfredo, Fratino Lucia, Lodde Michele, Messina Caterina, Perin Alessandra, Santini Daniele, Sava Teodoro, Tucci Marcello, Basso Umberto, Maines Francesca, Burgio Luca S, Galligioni Enzo. Clinical outcomes in octogenarians treated with docetaxel as first-line chemotherapy for castration-resistant prostate cancer.. Future oncology (London, England). 2016. DOI: 10.2217/fon.15.302.

Предметные рубрики MeSH

Aged, 80 and overAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsDocetaxelHumansMaleProportional Hazards ModelsProstatic Neoplasms, Castration-ResistantRetreatmentRetrospective StudiesTaxoidsTreatment Outcome
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