Медицинская библиотека · Human brain mapping · 2020
Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group.
Zugman André, Harrewijn Anita, Cardinale Elise M, Zwiebel Hannah, Freitag Gabrielle F, Werwath Katy E, Bas-Hoogendam Janna M, Groenewold Nynke A, Aghajani Moji, Hilbert Kevin, Cardoner Narcis, Porta-Casteràs Daniel, Gosnell Savannah, Salas Ramiro, Blair Karina S, Blair James R, Hammoud Mira Z, Milad Mohammed, Burkhouse Katie, Phan K Luan, Schroeder Heidi K, Strawn Jeffrey R, Beesdo-Baum Katja, Thomopoulos Sophia I, Grabe Hans J, Van der Auwera Sandra, Wittfeld Katharina, Nielsen Jared A, Buckner Randy, Smoller Jordan W, Mwangi Benson, Soares Jair C, Wu Mon-Ju, Zunta-Soares Giovana B, Jackowski Andrea P, Pan Pedro M, Salum Giovanni A, Assaf Michal, Diefenbach Gretchen J, Brambilla Paolo, Maggioni Eleonora, Hofmann David, Straube Thomas, Andreescu Carmen, Berta Rachel, Tamburo Erica, Price Rebecca, Manfro Gisele G, Critchley Hugo D, Makovac Elena, Mancini Matteo, Meeten Frances, Ottaviani Cristina, Agosta Federica, Canu Elisa, Cividini Camilla, Filippi Massimo, Kostić Milutin, Munjiza Ana, Filippi Courtney A, Leibenluft Ellen, Alberton Bianca A V, Balderston Nicholas L, Ernst Monique, Grillon Christian, Mujica-Parodi Lilianne R, van Nieuwenhuizen Helena, Fonzo Gregory A, Paulus Martin P, Stein Murray B, Gur Raquel E, Gur Ruben C, Kaczkurkin Antonia N, Larsen Bart, Satterthwaite Theodore D, Harper Jennifer, Myers Michael, Perino Michael T, Yu Qiongru, Sylvester Chad M, Veltman Dick J, Lueken Ulrike, Van der Wee Nic J A, Stein Dan J, Jahanshad Neda, Thompson Paul M, Pine Daniel S, Winkler Anderson M
СтатьяПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАОбзорПеревод пока не подготовлен
Аннотация
The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.
Для цитирования: Zugman André, Harrewijn Anita, Cardinale Elise M, Zwiebel Hannah, Freitag Gabrielle F, Werwath Katy E, Bas-Hoogendam Janna M, Groenewold Nynke A, Aghajani Moji, Hilbert Kevin, Cardoner Narcis, Porta-Casteràs Daniel, Gosnell Savannah, Salas Ramiro, Blair Karina S, Blair James R, Hammoud Mira Z, Milad Mohammed, Burkhouse Katie, Phan K Luan, Schroeder Heidi K, Strawn Jeffrey R, Beesdo-Baum Katja, Thomopoulos Sophia I, Grabe Hans J, Van der Auwera Sandra, Wittfeld Katharina, Nielsen Jared A, Buckner Randy, Smoller Jordan W, Mwangi Benson, Soares Jair C, Wu Mon-Ju, Zunta-Soares Giovana B, Jackowski Andrea P, Pan Pedro M, Salum Giovanni A, Assaf Michal, Diefenbach Gretchen J, Brambilla Paolo, Maggioni Eleonora, Hofmann David, Straube Thomas, Andreescu Carmen, Berta Rachel, Tamburo Erica, Price Rebecca, Manfro Gisele G, Critchley Hugo D, Makovac Elena, Mancini Matteo, Meeten Frances, Ottaviani Cristina, Agosta Federica, Canu Elisa, Cividini Camilla, Filippi Massimo, Kostić Milutin, Munjiza Ana, Filippi Courtney A, Leibenluft Ellen, Alberton Bianca A V, Balderston Nicholas L, Ernst Monique, Grillon Christian, Mujica-Parodi Lilianne R, van Nieuwenhuizen Helena, Fonzo Gregory A, Paulus Martin P, Stein Murray B, Gur Raquel E, Gur Ruben C, Kaczkurkin Antonia N, Larsen Bart, Satterthwaite Theodore D, Harper Jennifer, Myers Michael, Perino Michael T, Yu Qiongru, Sylvester Chad M, Veltman Dick J, Lueken Ulrike, Van der Wee Nic J A, Stein Dan J, Jahanshad Neda, Thompson Paul M, Pine Daniel S, Winkler Anderson M. Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group.. Human brain mapping. 2020. DOI: 10.1002/hbm.25096.
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