bioRxiv : the preprint server for biology · 2025
Zolpidem restores sleep and slows Alzheimer's progression in a mouse model.
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Yu Lu, Yokomizo Shinya, Doan Tri H, Zhao Qiuchen, Ganne Akshatha, Balasubramaniam Meenakshisundaram, Kastanenka Ksenia V
Аннотация
INTRODUCTION: Deficits in Non-Rapid Eye Movement (NREM) sleep facilitate Alzheimer's disease (AD) progression. Enhancing GABAergic signaling can restore sleep. Unbiased computational analysis identified zolpidem as high-affinity GABA receptor modulator facilitating chloride transport that could slow AD.
METHODS: Zolpidem's effects on sleep and Alzheimer's progression were evaluated in young APP/PS1 mice. Sleep was monitored with EEG/EMG telemetry. Widefield imaging with voltage-sensitive dyes was used to track sleep-dependent brain rhythms. Multiphoton microscopy allowed assessments of amyloid plaque load and basal neuronal calcium levels. Behavioral assays were used to measure memory and cognitive function.
RESULTS: Zolpidem restored NREM sleep and rescued sleep-dependent brain rhythm, slow oscillation. Zolpidem administration reduced cortical amyloid plaque burden, mitigated neuronal calcium overload, and enhanced sleep-dependent memory consolidation without adverse effects on locomotion.
DISCUSSION: Zolpidem effectively slowed Alzheimer's progression in young APP/PS1 mice. This supports zolpidem's therapeutic promise as an intervention strategy at early stages of AD.
METHODS: Zolpidem's effects on sleep and Alzheimer's progression were evaluated in young APP/PS1 mice. Sleep was monitored with EEG/EMG telemetry. Widefield imaging with voltage-sensitive dyes was used to track sleep-dependent brain rhythms. Multiphoton microscopy allowed assessments of amyloid plaque load and basal neuronal calcium levels. Behavioral assays were used to measure memory and cognitive function.
RESULTS: Zolpidem restored NREM sleep and rescued sleep-dependent brain rhythm, slow oscillation. Zolpidem administration reduced cortical amyloid plaque burden, mitigated neuronal calcium overload, and enhanced sleep-dependent memory consolidation without adverse effects on locomotion.
DISCUSSION: Zolpidem effectively slowed Alzheimer's progression in young APP/PS1 mice. This supports zolpidem's therapeutic promise as an intervention strategy at early stages of AD.