Electroporation as an adjunctive therapy for refractory feline sporotrichosis: A two-case report.

Feline sporotrichosis is a zoonotic subcutaneous mycosis often associated with high fungal burden and therapeutic challenges. This report describes two cases of feline sporotrichosis, caused by Sporothrix brasiliensis, unresponsive to itraconazole that were successfully managed using electroporation as an adjunctive local therapy. Both cats presented ulcerative and proliferative lesions with poor response to prolonged antifungal treatment. Electroporation was performed under general anesthesia using needle electrodes and square-wave electric pulses. Progressive reduction in lesion size, decreased exudation, and complete epithelialization were observed after repeated sessions. Complete remission was achieved after three sessions in one case and two sessions in the other, with no recurrence during follow-up. Electroporation may represent a useful adjunctive approach for local control of refractory sporotrichosis lesions, although further studies are needed to establish its efficacy.