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DOI 10.2147/ijnrd.s282106

Медицинская библиотека · International journal of nephrology and renovascular disease · 2020

Correlation Between Parathyroid Hormone Levels with Urinary Magnesium Excretion in Patients with Non-Dialysis Dependent Chronic Kidney Disease.

Carneiro Dias Raimunda Sheyla, José de Araújo Brito Dyego, Milhomem Dos Santos Elisângela, Cadilhe de Oliveira Costa Rayanna, Martins Melo Fontenele Andrea, Viana Hortegal Furtado Elane, Santos Lages Joyce, Miranda Dos Santos Alcione, Freitas Santos Elton Jonh, de Lima Carneiro Érika Cristina Ribeiro, Cruz Diniz Maria Célia, Trindade Barbosa Carla Déa, Costa de Sales Muniz Alessandra, Teixeira da Cunha França Ana Karina, Salgado Filho Natalino, Vianna Araújo Denizar, Bernardo-Filho Mário

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Аннотация

BACKGROUND

Disorders of mineral metabolism occur in most patients with chronic kidney disease (CKD). The aim of this work was to correlate parathyroid hormone (PTH) levels with urinary magnesium excretion in patients with non-dialysis dependent CKD.

METHODS

Cross-sectional study. Concentrations of creatinine, magnesium, calcium, phosphate, parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D] and alkaline phosphatase (ALP) were determined in blood samples. The assessment of urinary magnesium levels was performed by means of total daily excretion and by the excretion fraction (FEMg).

RESULTS

The study evaluated 163 patients with a mean age of 60.7 ± 11.7 years and 51.0% were male. In the highest quartile of PTH (>89.5pg/mL), the mean levels of FEMg and ALP were higher (p<0.05). In the unadjusted regression analysis, the following variables were related to serum PTH levels: FEMg (odds ratio (OR) = 1.12; 95% confidence intervals (CI): 1.02-1.23), calcium (OR = 0.45; 95% CI: 0.22-0.90), ALP (OR = 1.02; 95% CI: 1.00-1.03) and eGFR (OR = 0.92; 95% CI: 1.00-1.03). After an adjusted analysis, only one FEMg and ALP will remain correlated with PTH.

CONCLUSION

In patients with non-dialysis dependent CKD, FEMg and ALP were some variables that remained associated with PTH.

Для цитирования: Carneiro Dias Raimunda Sheyla, José de Araújo Brito Dyego, Milhomem Dos Santos Elisângela, Cadilhe de Oliveira Costa Rayanna, Martins Melo Fontenele Andrea, Viana Hortegal Furtado Elane, Santos Lages Joyce, Miranda Dos Santos Alcione, Freitas Santos Elton Jonh, de Lima Carneiro Érika Cristina Ribeiro, Cruz Diniz Maria Célia, Trindade Barbosa Carla Déa, Costa de Sales Muniz Alessandra, Teixeira da Cunha França Ana Karina, Salgado Filho Natalino, Vianna Araújo Denizar, Bernardo-Filho Mário. Correlation Between Parathyroid Hormone Levels with Urinary Magnesium Excretion in Patients with Non-Dialysis Dependent Chronic Kidney Disease.. International journal of nephrology and renovascular disease. 2020. DOI: 10.2147/ijnrd.s282106.
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