Neuropsychological differentiation of late-onset schizophrenia and dementia of the Alzheimer's type.

Late-onset schizophrenia and dementia of the Alzheimer's type (DAT) often present with some pathological and behavioral commonalities. Specifically, both illnesses may involve varying degrees of delusional manifestation, apathy, lateral/third-ventricular enlargement, reduced frontal lobe activity, and hippocampal atrophy. Moreover, patients with either disease have shown comparable cognitive impairment on standardized neuropsychological tests. As such, a differential diagnosis of the 2 disorders on the basis of such testing can prove to be difficult. This study evaluated the neuropsychological test results of 32 patients with late-onset schizophrenia and 32 patients with DAT to distinguish the tests that best differentiate the 2 disorders. Results indicate that the Wechsler Adult Intelligence Scale-Revised Similarities subtest and the California Verbal Learning Test (both short- and long-delay free recall) correspond to sensitive diagnostic neuropsychological measures. This investigation was preliminary in nature, and should aid in the development of a definitive differential profile.