Experimental eye research · 2026
Oral crocin promotes corneal epithelial healing and attenuates opacity and neovascularization in a rat model of alkali-induced corneal injury.
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Horozoglu Ceran Tugce, Kayabas Huseyin, Ay Ibrahim Ethem, Dogan Mustafa
Аннотация
PURPOSE: To evaluate the effects of oral crocin on corneal epithelial healing, edema, opacity, and neovascularization in a rat model of alkali-induced corneal injury.
METHODS: This controlled experimental study included 28 female Wistar albino rats with standardized unilateral alkali-induced corneal burns. Rats were randomized to vehicle control, crocin 100 mg/kg/day, crocin 200 mg/kg/day, or crocin 300 mg/kg/day groups, with seven rats per group. Alkali injury was induced using 1 N sodium hydroxide. Treatments were administered once daily by oral gavage for 42 days. Epithelial defect, corneal opacity, and corneal neovascularization areas were quantified. Corneal edema and haze were evaluated using semiquantitative clinical grading. Repeated-measures and nonparametric tests were used as appropriate.
RESULTS: Baseline epithelial defect areas were comparable among groups. At D3 and D7, crocin-treated rats had significantly smaller epithelial defects than vehicle-treated controls, indicating faster early epithelial recovery. Corneal opacity area was significantly lower in all crocin-treated groups than in controls from D3 to D42. Corneal neovascularization area was significantly lower in the Crocin 300 group at D7 and in all crocin-treated groups from D21 onward. Corneal edema scores were lower from D3 to D42, and corneal haze scores were lower from D7 to D42. No consistent dose-dependent separation was observed, although 300 mg/kg/day showed the earliest significant antiangiogenic effect.
CONCLUSIONS: Oral crocin was associated with faster epithelial healing and lower corneal edema, haze, opacity area, and neovascularization after alkali-induced corneal injury in rats. These findings suggest adjunctive therapeutic potential in chemical corneal injury, warranting further mechanistic and translational studies.
METHODS: This controlled experimental study included 28 female Wistar albino rats with standardized unilateral alkali-induced corneal burns. Rats were randomized to vehicle control, crocin 100 mg/kg/day, crocin 200 mg/kg/day, or crocin 300 mg/kg/day groups, with seven rats per group. Alkali injury was induced using 1 N sodium hydroxide. Treatments were administered once daily by oral gavage for 42 days. Epithelial defect, corneal opacity, and corneal neovascularization areas were quantified. Corneal edema and haze were evaluated using semiquantitative clinical grading. Repeated-measures and nonparametric tests were used as appropriate.
RESULTS: Baseline epithelial defect areas were comparable among groups. At D3 and D7, crocin-treated rats had significantly smaller epithelial defects than vehicle-treated controls, indicating faster early epithelial recovery. Corneal opacity area was significantly lower in all crocin-treated groups than in controls from D3 to D42. Corneal neovascularization area was significantly lower in the Crocin 300 group at D7 and in all crocin-treated groups from D21 onward. Corneal edema scores were lower from D3 to D42, and corneal haze scores were lower from D7 to D42. No consistent dose-dependent separation was observed, although 300 mg/kg/day showed the earliest significant antiangiogenic effect.
CONCLUSIONS: Oral crocin was associated with faster epithelial healing and lower corneal edema, haze, opacity area, and neovascularization after alkali-induced corneal injury in rats. These findings suggest adjunctive therapeutic potential in chemical corneal injury, warranting further mechanistic and translational studies.