Arquivos de neuro-psiquiatria · 2013
Exposure to pesticides and heterozygote genotype of GSTP1-Alw26I are associated to Parkinson's disease.
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Longo Gabriela S, Pinhel Marcela S, Sado Caroline L, Gregório Michele L, Amorim Gisele S, Florim Greiciane S, Mazeti Camila M, Martins Denise P, Oliveira Fábio N, Tognola Waldir A, Nakazone Marcelo A, Souza Dorotéia R S
Аннотация
OBJECTIVE: This study aimed to analyze the frequency of GSTP1-Alw26I polymorphism and to estimate its association with toxic substances in Parkinson's disease (PD).
METHODS: A study group with 154 patients - subdivided into familial and sporadic PD groups - and 158 elderly individuals without the disease (control group) were evaluated. GSTP1-Alw26I polymorphism was analyzed by polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP).
RESULTS: Patients were significantly more exposed to pesticides compared with the control group (p=0.0004), and the heterozygote genotype associated to exposure to pesticides also prevailed in patients (p=0.0001). Wild homozygote genotype was related to tobacco use (p=0.043) and alcoholism (p=0.033) in familial PD patients.
CONCLUSION: Exposure to pesticides is associated to PD, whose effect can be enhanced when combined with the heterozygote genotype of GSTP1-Alw26I. Also, large genetic and environmental studies considering tobacco use, alcoholism, GSTP1 and PD are necessary to confirm our findings.
METHODS: A study group with 154 patients - subdivided into familial and sporadic PD groups - and 158 elderly individuals without the disease (control group) were evaluated. GSTP1-Alw26I polymorphism was analyzed by polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP).
RESULTS: Patients were significantly more exposed to pesticides compared with the control group (p=0.0004), and the heterozygote genotype associated to exposure to pesticides also prevailed in patients (p=0.0001). Wild homozygote genotype was related to tobacco use (p=0.043) and alcoholism (p=0.033) in familial PD patients.
CONCLUSION: Exposure to pesticides is associated to PD, whose effect can be enhanced when combined with the heterozygote genotype of GSTP1-Alw26I. Also, large genetic and environmental studies considering tobacco use, alcoholism, GSTP1 and PD are necessary to confirm our findings.
Предметные рубрики MeSH
AgedAged, 80 and overCase-Control StudiesDNA-Cytosine MethylasesFemaleGene FrequencyGlutathione S-Transferase piHeterozygoteHumansMaleMiddle AgedParkinson Disease, SecondaryPesticidesPolymerase Chain ReactionPolymorphism, GeneticRisk FactorsSex FactorsSite-Specific DNA-Methyltransferase (Adenine-Specific)