Cancer diagnosis & prognosis · 2022
Undifferentiated Pleomorphic Sarcoma of the Conjunctiva: A Case Report and Review of the Literature.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Suimon Yuka, Kase Satoru, Mitsuhashi Tomoko, Ishida Susumu
Аннотация
BACKGROUND/AIM: Undifferentiated pleomorphic sarcoma (UPS), previously called as malignant fibrous histiocytoma, is a mesenchymal neoplasm which shows no identifiable cellular differentiation when analyzed by presently available technology. UPS in the periocular region is extremely rare. This study describes a patient with UPS arising in the conjunctiva with literature review.
CASE REPORT: A 66-year-old man presented with a congested mass on the bulbar conjunctiva. The mass was totally excised. Histopathologically, it was a dome-shaped tumor comprising atypical short spindle cells growing as pattern-less pattern, with enlarged nuclei and eosinophilic cytoplasm. Based on immunohistochemistry, the direction of cellular differentiation was unidentifiable; therefore, it was diagnosed as UPS. The tumor showed high Ki-67 labeling index (70~80%).
CONCLUSION: Twelve patients with conjunctival UPS have been reported with an average age of 49 years. Eight tumors of the 12 patients were observed in the limbus, and the rest in the bulbar conjunctiva. The appearance of the tumors was yellow, tan, pink, brown, or vascularized. Histopathologically, the tumors consisted of spindle-shaped cells with pleomorphism and many mitotic figures. In conclusion, conjunctival UPS is a rare malignancy with various colors, which can show aggressive nature. UPS should be differentiated from other conjunctival malignancies based on histopathological and immunohistochemical examinations including Ki-67.
CASE REPORT: A 66-year-old man presented with a congested mass on the bulbar conjunctiva. The mass was totally excised. Histopathologically, it was a dome-shaped tumor comprising atypical short spindle cells growing as pattern-less pattern, with enlarged nuclei and eosinophilic cytoplasm. Based on immunohistochemistry, the direction of cellular differentiation was unidentifiable; therefore, it was diagnosed as UPS. The tumor showed high Ki-67 labeling index (70~80%).
CONCLUSION: Twelve patients with conjunctival UPS have been reported with an average age of 49 years. Eight tumors of the 12 patients were observed in the limbus, and the rest in the bulbar conjunctiva. The appearance of the tumors was yellow, tan, pink, brown, or vascularized. Histopathologically, the tumors consisted of spindle-shaped cells with pleomorphism and many mitotic figures. In conclusion, conjunctival UPS is a rare malignancy with various colors, which can show aggressive nature. UPS should be differentiated from other conjunctival malignancies based on histopathological and immunohistochemical examinations including Ki-67.