Physiological genomics analysis for central diabetes insipidus.

Central diabetes insipidus (CDI) is a neuroendocrine disorder that has the highest prevalence. This disorder can be found in all countries around the world. Although CDI has been studied for a long time, it is still not clear whether this is a genetic disorder. Systemic approach on the pathophysiology and genomics might provide useful information to better understand the pathogenesis of CDI. In this work, physiological genomics analysis for CDI was performed. Based on this work, there are two genes identified with high physiogenomics relationship. They are Arginine vasopressin (AVP) on chromosome 20 and AVP receptor 2 (AVPR2) on chromosome X. Physiogenomics approach could be a novel and useful tool for researches.