Inhibition of nitric oxide synthesis leads to reduced parasitemia in murine Trypanosoma brucei infection.

In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.