EBF1: A Multidimensional Role Integrating Metabolism and Metabolic Diseases.

INTRODUCTION

Early B-cell factor 1 (EBF1) is a multifunctional transcription factor. It plays a pivotal role in regulating biological processes such as B-lymphocyte development and neuronal differentiation. EBF1 has been implicated in metabolic disorders such as diabetes and central obesity through epigenetic modifications and underlying signaling pathways. However, the molecular mechanisms and functions of EBF1's direct regulation of metabolic targets have yet to be systematically analyzed. This review aims to integrate the multidimensional functions and regulatory networks of EBF1 in metabolic control, while summarizing its mechanistic contributions to metabolic diseases.

METHODS

This review systematically summarizes and speculates on the biological functions and related mechanisms of EBF1 in normal metabolic activities and metabolic diseases by comprehensively searching the current studies through the PubMed database.

RESULTS

(1) EBF1 promotes lipogenesis during early adipocyte differentiation. (e.g., PPARγ and C/EBPα) (2) EBF1 regulates insulin signaling (e.g., PI3K/AKT, MAPK) and inflammatory pathways (e.g., Toll-like receptors, JAK-STAT) in mature adipocytes. (3) EBF1 SNPs and methylation play crucial roles in various metabolic disorders.

DISCUSSION: EBF1 plays a crucial role in both early adipocyte differentiation and the maintenance of homeostasis in mature adipocytes; however, these findings may vary across models. The epigenetic regulation of EBF1 is a key mechanism underlying metabolic dysregulation and warrants further investigation.

CONCLUSION

Given its multifaceted roles in lipogenesis, inflammation, and insulin resistance, EBF1 holds potential as a diagnostic biomarker and therapeutic target for various metabolic diseases.