Kidney & blood pressure research · 2015
Induction of apoptosis by hypertension via endoplasmic reticulum stress.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sun Yingying, Zhang Tong, Li Li, Wang Ji
Аннотация
BACKGROUND/AIMS: Endoplasmic reticulum (ER) stress is one of the intrinsic apoptosis pathways, and cardiac apoptosis can occur in cardiovascular diseases, such as hypertension. However, the mechanisms by which ER stress leads to apoptosis remain enigmatic, particularly in the progression from cardiac hypertrophy to diastolic heart failure due to hypertension.
METHODS: We used spontaneously hypertensive rats (SHRs) to investigate possible signalling pathways for ER stress.
RESULTS: We found that cardiac protein and mRNA levels of glucoseregulated protein 78 were up-regulated. In addition, the CHOP- and caspase-12-dependent pathways, but not that of JNK, were activated in the SHR rats.
CONCLUSIONS: These results suggest that ER stress can contribute to myocardial apoptosis during hypertensive disease.
METHODS: We used spontaneously hypertensive rats (SHRs) to investigate possible signalling pathways for ER stress.
RESULTS: We found that cardiac protein and mRNA levels of glucoseregulated protein 78 were up-regulated. In addition, the CHOP- and caspase-12-dependent pathways, but not that of JNK, were activated in the SHR rats.
CONCLUSIONS: These results suggest that ER stress can contribute to myocardial apoptosis during hypertensive disease.