[Drug resistance analysis of pan-drug-resistant Acinetobacter baumannii in hospital].

OBJECTIVE

To investigate current situation of pan-drug-resistant Acinetobacter baumannii in hospital and its drug-resistance , then provide reference for rational use of antibiotics in clinic.

METHODS

All kinds of microbial test specimens from January 2009 to December 2012 of hospitalized patients were cultured and separated. VITEK 2-Compact fully automatic microorganism analyzer was used to identify and analyze drug sensitivity.

RESULTS

Three hundred and seven strains pan-drug-resistant Acinetobacter baumannii were isolated in 4 years, the primarily source were sputum, accounted for 69.4%, followed by the wound secretion 14.7%. The highest three places of samples separation of extensive drug-resistant Acinetobacter baumannii positive was intensive care unit (ICU, accounted for 26.4%), department of respiratory medicine (accounted for 26.1%) and department of geriatrics (accounted for 23.1%). Extensive drug-resistant Acinetobacter baumannii almost completely resisted to clinical commonly used antimicrobial agents, drug resistant rate could be as high as 100% such as cefotaxime, meropenem, piperacillin, imipenem, ciprofloxacin, and tetracycline except for cefoperazone-sulbactam and polymyxin, and the rate of other drugs were all above 90%. Drug-resistant of cefoperazone-sulbactam was nearly 30% in our hospital, and sensitive rate was 100% to polymyxin.

CONCLUSIONS

Pan-drug-resistant Acinetobacter baumannii is resistant for most clinical commonly used antimicrobial drug, antimicrobial agents were chosen according to drug susceptibility testing. Antibacterial drugs such as polymyxin and cefoperazone-sulbactam or sulbactam contained drugs can be selected for pan-drug-resistant.