Fertility and sterility · 1992
Platelet-activating factor acetylhydrolase in human seminal plasma.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Letendre E D, Miron P, Roberts K D, Langlais J
Аннотация
OBJECTIVE: To search for the presence of platelet-activating factor (PAF) acetylhydrolase activity in human seminal plasma.
DESIGN: Experimental.
SETTING: Reproductive laboratory in a university-affiliated hospital research center.
PARTICIPANTS: Human male volunteers were selected on the basis of apparent normal health.
RESULTS: Human seminal plasma contained significant levels of PAF-acetylhydrolase activity. Enzymatic hydrolysis of PAF displayed typical kinetics and was a calcium-independent process. Platelet-activating factor acetylhydrolase in seminal plasma was associated with a very high-density lipoprotein fraction. Enzymatic activity was independent of sperm count and motility.
CONCLUSION: Human seminal plasma contains significant levels of PAF acetylhydrolase. This enzyme may be an important factor in the regulation of PAF concentration and activity.
DESIGN: Experimental.
SETTING: Reproductive laboratory in a university-affiliated hospital research center.
PARTICIPANTS: Human male volunteers were selected on the basis of apparent normal health.
RESULTS: Human seminal plasma contained significant levels of PAF-acetylhydrolase activity. Enzymatic hydrolysis of PAF displayed typical kinetics and was a calcium-independent process. Platelet-activating factor acetylhydrolase in seminal plasma was associated with a very high-density lipoprotein fraction. Enzymatic activity was independent of sperm count and motility.
CONCLUSION: Human seminal plasma contains significant levels of PAF acetylhydrolase. This enzyme may be an important factor in the regulation of PAF concentration and activity.