Retina (Philadelphia, Pa.) · 2025
INTRAVITREAL BEVACIZUMAB FOR THE TREATMENT OF CHOROIDAL HEMANGIOMAS.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Elkayal Hassan E, Sagoo Mandeep S, Negretti Guy S
Аннотация
PURPOSE: To investigate the use of intravitreal bevacizumab for the treatment of subretinal fluid (SRF) and intraretinal fluid associated with circumscribed choroidal hemangiomas.
METHODS: This was a retrospective review of all patients treated with at least three bevacizumab injections for circumscribed choroidal hemangiomas-associated SRF between May 2020 and August 2023 in Moorfields eye hospital. Outcome measures included change in best-corrected visual acuity, change in patient-reported symptoms, change in SRF, and change in central subfield thickness. Data on further management after cessation of injections were analyzed.
RESULTS: The study included nine patients. Median best-corrected visual acuity was 6/19 before and 6/24 after injections ( P = 0.41). Central subfield thickness decreased from a median of 466 to 447 µ m ( P = 0.11). Two thirds of (n = 6) patients did not show any reduction in foveal SRF, one third (n = 3) showed a partial reduction, and no patients had a complete resolution of SRF. Eight patients received rescue-photodynamic therapy, and one received external beam radiotherapy. Best-corrected visual acuity changed from a median of 6/60 to a median of 6/12 after rescue treatment ( P = 0.63). The median central subfield thickness decreased significantly from 470 µ m to 249 µ m ( P = 0.01).
CONCLUSION: Intravitreal bevacizumab is unlikely to be an effective treatment for exudative circumscribed choroidal hemangiomas.
METHODS: This was a retrospective review of all patients treated with at least three bevacizumab injections for circumscribed choroidal hemangiomas-associated SRF between May 2020 and August 2023 in Moorfields eye hospital. Outcome measures included change in best-corrected visual acuity, change in patient-reported symptoms, change in SRF, and change in central subfield thickness. Data on further management after cessation of injections were analyzed.
RESULTS: The study included nine patients. Median best-corrected visual acuity was 6/19 before and 6/24 after injections ( P = 0.41). Central subfield thickness decreased from a median of 466 to 447 µ m ( P = 0.11). Two thirds of (n = 6) patients did not show any reduction in foveal SRF, one third (n = 3) showed a partial reduction, and no patients had a complete resolution of SRF. Eight patients received rescue-photodynamic therapy, and one received external beam radiotherapy. Best-corrected visual acuity changed from a median of 6/60 to a median of 6/12 after rescue treatment ( P = 0.63). The median central subfield thickness decreased significantly from 470 µ m to 249 µ m ( P = 0.01).
CONCLUSION: Intravitreal bevacizumab is unlikely to be an effective treatment for exudative circumscribed choroidal hemangiomas.
Предметные рубрики MeSH
HumansBevacizumabChoroid NeoplasmsIntravitreal InjectionsRetrospective StudiesAngiogenesis InhibitorsFemaleMaleHemangiomaVisual AcuityMiddle AgedTomography, Optical CoherenceAdultAgedFluorescein AngiographySubretinal FluidTreatment OutcomeFollow-Up StudiesFundus OculiVascular Endothelial Growth Factor A