Retina (Philadelphia, Pa.) · 2025
ASSESSING THE REPEATABILITY OF INNER CHOROID FLOW DEFICIT PERCENTAGE IN INTERMEDIATE AGE-RELATED MACULAR DEGENERATION AND CONTROLS: A Comparative Study Between Different Post-Processing Approaches.
СтатьяНаблюдательное исследованиеСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Romano Francesco, Ding Xinyi, Garcia Mauricio, Zhao Yan, Vingopoulos Filippos, Garg Itika, Stettler Isabella, Bennett Cade, Overbey Katherine, Finn Matthew J, Ploumi Ioanna, Laìns Inês, Patel Nimesh A, Wu David M, Vavvas Demetrios G, Husain Deeba, Miller Joan W, Miller John B
Аннотация
PURPOSE: To assess repeatability of macular inner choroid flow deficit percentage in intermediate age-related macular degeneration and controls using various postprocessing approaches.
METHODS: Cross-sectional, observational study. The authors included 1) 22 intermediate age-related macular degeneration and 24 control eyes, with 2) age >50 years, 3) visual acuity >20/32, and 4) no additional ocular and systemic confounders. Participants underwent four consecutive 6 × 6-mm optical coherence tomography angiography scans (2 acquired at 100-kHz and 2 at 200-kHz speed; PLEX Elite 9000) for intrasession analysis. Same protocol was repeated after 30 minutes for intersession analysis. Three slabs of different thicknesses were generated underneath Bruch membrane (4-14, 4-19, 4-24 µ m). All slabs were processed with: 1) binarization-only using Phansalkar method (r = 4-15 pixels); 2) compensation + binarization; 3) averaging + binarization; 4) averaging + compensation + binarization. Inner choroid flow deficit percentage was measured within 3-mm and 5-mm circles, and measurements were repeated after excluding drusen areas. Repeatability was analyzed with generalized linear mixed-effects models, intraclass correlation coefficients, and Levene variance test.
RESULTS: Most postprocessing approaches demonstrated high repeatability (intraclass correlation coefficient >0.75) with no significant test-retest differences ( P > 0.05). Compensation + binarization of 15- µ m slabs at 200 kHz showed the highest repeatability (intraclass correlation coefficient: 0.96-0.98). Excluding drusen did not significantly affect inner choroid flow deficit percentage measurements ( P > 0.05), showing increased intraclass correlation coefficients for 10-µm-thick and binarized-only slabs.
CONCLUSION: Strong repeatability can be achieved with various postprocessing methods for assessing inner choroid flow deficit percentage, especially with compensation + binarization of 15- µ m slabs acquired at 200 kHz. Drusen removal does not seem to affect repeatability in intermediate age-related macular degeneration when using a swept-source device, except for specific settings. These results contribute to refining choriocapillaris assessment, paving the way for future applications.
METHODS: Cross-sectional, observational study. The authors included 1) 22 intermediate age-related macular degeneration and 24 control eyes, with 2) age >50 years, 3) visual acuity >20/32, and 4) no additional ocular and systemic confounders. Participants underwent four consecutive 6 × 6-mm optical coherence tomography angiography scans (2 acquired at 100-kHz and 2 at 200-kHz speed; PLEX Elite 9000) for intrasession analysis. Same protocol was repeated after 30 minutes for intersession analysis. Three slabs of different thicknesses were generated underneath Bruch membrane (4-14, 4-19, 4-24 µ m). All slabs were processed with: 1) binarization-only using Phansalkar method (r = 4-15 pixels); 2) compensation + binarization; 3) averaging + binarization; 4) averaging + compensation + binarization. Inner choroid flow deficit percentage was measured within 3-mm and 5-mm circles, and measurements were repeated after excluding drusen areas. Repeatability was analyzed with generalized linear mixed-effects models, intraclass correlation coefficients, and Levene variance test.
RESULTS: Most postprocessing approaches demonstrated high repeatability (intraclass correlation coefficient >0.75) with no significant test-retest differences ( P > 0.05). Compensation + binarization of 15- µ m slabs at 200 kHz showed the highest repeatability (intraclass correlation coefficient: 0.96-0.98). Excluding drusen did not significantly affect inner choroid flow deficit percentage measurements ( P > 0.05), showing increased intraclass correlation coefficients for 10-µm-thick and binarized-only slabs.
CONCLUSION: Strong repeatability can be achieved with various postprocessing methods for assessing inner choroid flow deficit percentage, especially with compensation + binarization of 15- µ m slabs acquired at 200 kHz. Drusen removal does not seem to affect repeatability in intermediate age-related macular degeneration when using a swept-source device, except for specific settings. These results contribute to refining choriocapillaris assessment, paving the way for future applications.