American journal of ophthalmology case reports · 2024
A case of corneal opacity caused by atovaquone administration.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ashizuka Takeyoshi, Uematsu Masafumi, Mohamed Mohamed Talaat, Kusano Mao, Helmy Mohamed Yasser, Inoue Daisuke, Kitaoka Takashi
Аннотация
PURPOSE: Atovaquone is an alternative drug that is used for the prevention and treatment of Pneumocystis pneumonia when the first-line drug, sulfamethoxazole-trimethoprim (ST combination), cannot be used due to side effects. However, atovaquone is known to cause ocular side effects including oculomucocutaneous syndrome and vortex keratopathy. In this report, we describe a patient who developed bilateral white granular diffuse corneal opacity that extended from the corneal sub-epithelium to the stroma after continuous oral atovaquone administration for 14 months.
OBSERVATIONS: The patient was a 15-year-old male with no prior ophthalmological or family medical history, but with a medical history of aplastic anemia treatment at our hospital's pediatric department. Examination showed bilateral diffuse white granular corneal opacity that extended from the sub-epithelium to the stroma, with no other abnormalities in the anterior and posterior segments of both eyes.
CONCLUSIONS AND IMPORTANCE: We encountered a rare case of bilateral corneal opacity resulting from oral atovaquone administration. Regular long-term ophthalmological examinations are necessary for patients taking atovaquone.
OBSERVATIONS: The patient was a 15-year-old male with no prior ophthalmological or family medical history, but with a medical history of aplastic anemia treatment at our hospital's pediatric department. Examination showed bilateral diffuse white granular corneal opacity that extended from the sub-epithelium to the stroma, with no other abnormalities in the anterior and posterior segments of both eyes.
CONCLUSIONS AND IMPORTANCE: We encountered a rare case of bilateral corneal opacity resulting from oral atovaquone administration. Regular long-term ophthalmological examinations are necessary for patients taking atovaquone.