Journal of endodontics · 2025
The Mystifying Role of Mast Cells in the Pathogenesis of Periapical Pathologies - A Systematic Review.
Систематический обзорСтатьяНазвание и аннотация: Перевод в очереди
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Kamboj Mala, Malik Shashibala, Keerthika R, Narwal Anjali, Devi Anju, Vijayakumar Gopikrishnan, Kumar Adarsh
Аннотация
INTRODUCTION: Oral periapical lesions present a significant global health burden, with their pathogenesis shrouded in complexity due to multifaceted mechanisms. Despite extensive research, the precise role of mast cells in their pathogenesis remains elusive. The present systematic review aimed to elucidate the mechanism of mast cells in the immunopathology of periapical lesions.
METHODS: An extensive literature search conducted across databases (MEDLINE via PubMed, Scopus, Cochrane Library, and EMBASE and gray literature) of original research articles that examined the role of mast cells in periapical lesions were investigated and selected for review. The risk of bias for each study was meticulously assessed using the QUADAS-2, and Review Manager 5.4 (RevMan v5.4, The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) was utilized to generate the results.
RESULTS: A total of 41 published articles were included for data synthesis. The findings revealed significant variations in mast cell number within the fibrous capsule of periapical granuloma and periapical cyst, with notably elevated counts in the latter. Periapical granuloma manifested a predominance of granulated mast cells in the subepithelial region. In contrast, the periapical cyst exhibited a preponderance of degranulated mast cells in the deeper areas of the capsule.
CONCLUSIONS: The current evidence substantiates that mast cells play a crucial role in the pathogenesis, progression, fibrosis, and chronicity of periapical lesions.
METHODS: An extensive literature search conducted across databases (MEDLINE via PubMed, Scopus, Cochrane Library, and EMBASE and gray literature) of original research articles that examined the role of mast cells in periapical lesions were investigated and selected for review. The risk of bias for each study was meticulously assessed using the QUADAS-2, and Review Manager 5.4 (RevMan v5.4, The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) was utilized to generate the results.
RESULTS: A total of 41 published articles were included for data synthesis. The findings revealed significant variations in mast cell number within the fibrous capsule of periapical granuloma and periapical cyst, with notably elevated counts in the latter. Periapical granuloma manifested a predominance of granulated mast cells in the subepithelial region. In contrast, the periapical cyst exhibited a preponderance of degranulated mast cells in the deeper areas of the capsule.
CONCLUSIONS: The current evidence substantiates that mast cells play a crucial role in the pathogenesis, progression, fibrosis, and chronicity of periapical lesions.