Correlation between serum adiponectin and risk factors in patients with coronary artery disease.

BACKGROUND

To investigate the correlation between serum adiponectin (ADP) and high sensitivity C-reactive protein (hsCRP) as well as risk factors in patients with coronary artery disease (CAD).

METHODS

90 patients with coronary artery disease (CAD) who were subjected to coronary angiography were involved. Among the patients, 41 had acute myocardial infarction (AMI), 27 had unstable angina pectoris (UAP), and 22 had stable angina pectoris (SAP). 20 healthy people comprised the control group (NC). Serum ADP was measured using an enzyme linked immunosorbent assay (ELISA). hsCRP was measured using immunoturbidimetry. Cardiovascular risk factors were also investigated.

RESULTS

The serum ADP concentrations in the AMI group and the UAP group were significantly lower than those in the SAP group (p < 0.05) and the NC group (p < 0.01). The hsCRP concentrations in the AMI group and the UAP group were significantly higher than those in the SAP group (p < 0.05) and the NC group (p < 0.05). The ADP concentration was negatively correlated with the hsCRP concentration in the acute coronary syndrome group (r = -0.33, p < 0.05). Moreover, the more risk factors there were, the lower the serum ADP concentration in the CAD patients was.

CONCLUSIONS

Serum ADP is associated with CAD and cardiovascular risk factors. ADP has anti-inflammatory and anti-atherogenic properties, which may have a predictive value for the genesis and development of ACS.