Prognostic Implications of Natural Killer (NK) Cells in Metastatic Cervical Lymph Nodes of Oral Carcinoma Patients.
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Glavin Daniel P, Dworkin Jason P, Alexander Conel M O'D, Aponte José C, Baczynski Allison A, Barnes Jessica J, Bechtel Hans A, Berger Eve L, Burton Aaron S, Caselli Paola, Chung Angela H, Clemett Simon J, Cody George D, Dominguez Gerardo, Elsila Jamie E, Farnsworth Kendra K, Foustoukos Dionysis I, Freeman Katherine H, Furukawa Yoshihiro, Gainsforth Zack, Graham Heather V, Grassi Tommaso, Giuliano Barbara Michela, Hamilton Victoria E, Haenecour Pierre, Heck Philipp R, Hofmann Amy E, House Christopher H, Huang Yongsong, Kaplan Hannah H, Keller Lindsay P, Kim Bumsoo, Koga Toshiki, Liss Michael, McLain Hannah L, Marcus Matthew A, Matney Mila, McCoy Timothy J, McIntosh Ophélie M, Mojarro Angel, Naraoka Hiroshi, Nguyen Ann N, Nuevo Michel, Nuth Joseph A, Oba Yasuhiro, Parker Eric T, Peretyazhko Tanya S, Sandford Scott A, Santos Ewerton, Schmitt-Kopplin Philippe, Seguin Frederic, Simkus Danielle N, Shahid Anique, Takano Yoshinori, Thomas-Keprta Kathie L, Tripathi Havishk, Weiss Gabriella, Zheng Yuke, Lunning Nicole G, Righter Kevin, Connolly Harold C, Lauretta Dante S
Аннотация
METHODS: We performed a systematic literature review following the PRISMA 2020 guidelines. The research was carried out using the PUBMED database and the following search terms: ((Metastatic) OR (metastases) OR (metastasis) OR (metastasizing)) AND (pleomorphic adenoma). The inclusion criteria for the final selection were: case reports or case series as study designs, availability of full text, and diseases specific to the parotid gland. Review articles, articles without full text, and studies on salivary glands other than the parotid gland were excluded.
RESULTS: A total of 908 papers were initially selected and 42 patients. The mean age at the diagnosis of MPA was 49.2 years (range 13-75 years). The average interval of onset of first metastasis was 15.7 years (range 1.4-45 years). The most common sites of metastasis were the bones (23.8%) and lungs (23.8%). In 31 patients (73.8%) a surgical treatment for complete removal of MPA was performed, while 10 patients withstood definitive or adjuvant radiotherapy. The follow up status was described only in 22 out of 40 papers where only 3 patients died from the neoplasm.
CONCLUSION: MPA of the parotid gland is a rare condition. The transformation of a PA to MPA is unpredictable. Because of the scarcity of data in the literature, the long-term behaviour of metastatic neoplasm is uncertain. However, we found that 5 out of 19 patients experienced disease relapse after treatment. Additionally, the average survival rate for individuals with MPA of the parotid gland is 64% after 5 years. The preferred course of treatment, if possible, is the surgical removal of the neoplasm.