[Basic and clinical aspects of calcimimetics. Beneficial and adverse effects of calcimimetics on various organs].

It is unknown about beneficial or harmful effects of calcimimetic, which is a selective, allosteric agonist for calcium sensing receptor (CaSR) , on various organs, excluding parathyroid gland. While the distribution of CaSR is broad, in addition to hypocalcemia-induced symptoms, either nausea or vomiting is the only adverse symptoms by calcimimetics. In this review, the mechanism of nausea or vomiting, as well as the beneficial or harmful effects upon some organs (e.g. bone, kidney and vessel) , are extrapolated.