Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2000
Lichen planus--specific antigen in oral lichen planus and oral lichenoid drug eruptions.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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McCartan B E, Lamey P
Аннотация
OBJECTIVE: To investigate the usefulness of lichen planus-specific antigen as a marker to distinguish idiopathic oral lichen planus from oral lichenoid drug eruptions.
STUDY DESIGN: Biopsy samples were taken from 6 patients with oral lichenoid drug eruptions and 6 patients with idiopathic oral lichen planus. Each biopsy sample was examined for the presence of lichen planus-specific antigen by using a modification of a previously described immunofluorescence method that uses autologous serum and also allogenic sera from the remaining 11 cases.
RESULTS: All autologous and allogenic immunofluorescence tests showed negative findings for lichen planus-specific antigen.
CONCLUSIONS: Lichen planus-specific antigen is not a useful marker to distinguish oral lichenoid drug eruptions from idiopathic lichen planus. This finding is in contrast with our findings in an earlier study of basal cell cytoplasmic autoantibodies.
STUDY DESIGN: Biopsy samples were taken from 6 patients with oral lichenoid drug eruptions and 6 patients with idiopathic oral lichen planus. Each biopsy sample was examined for the presence of lichen planus-specific antigen by using a modification of a previously described immunofluorescence method that uses autologous serum and also allogenic sera from the remaining 11 cases.
RESULTS: All autologous and allogenic immunofluorescence tests showed negative findings for lichen planus-specific antigen.
CONCLUSIONS: Lichen planus-specific antigen is not a useful marker to distinguish oral lichenoid drug eruptions from idiopathic lichen planus. This finding is in contrast with our findings in an earlier study of basal cell cytoplasmic autoantibodies.