[Concentration of proinflammatory and antiinflammatory cytokines in blood and wound of patients with odontogenic phlegmons].

Levels of IL-1beta, IL-6, TNFalpha, IL-10 and TGF-beta in blood and wound of 56 patients with odontogenic phlegmons in dynamic of infection process were expected. In accordance with known facts production of proinflammatory cytokines (IL-1beta, IL-6, TNFalpha in blood in acute phase of the inflammation process was much more intensive than in normal conditions. Increased proinflammatory cytokines generation led to significant raising of IL-10 concentration, but elevation of its level in blood was only at the 10-14 the days of therapy. The dynamic of these cytokines concentrations in wound were similar. On other side the negative role in regeneration of wound plays TGFbeta. Minimal concentration of this cytokine in blood was found at 1-3 from treatment beginning. On the background of the intensive therapy the level of TGFbeta raised fastly and at 10-14 days was much more than in control conditions. Wound level of TGFbeta was more than in normal conditions from the third day. These changes may be one of the reason of hyper proliferation of keratinocytes, that led rough scars.