Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
Subungual verrucous carcinoma of the thumb treated by intra-arterial infusion with methotrexate.
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Sheen Maw-Chang, Sheen Yi-Shuan, Sheu Hamm-Ming, Wong Tak-Wah, Lee Yu-Yun, Wu Chih-Fung, Wang Yi-Wen, Chai Chee-Yin
Аннотация
BACKGROUND: For preservation of integrity of appearance and function in a 66-year-old male with an extremely rare case of verrucous carcinoma developing from the subungium of his right thumb, intra-arterial infusion with methotrexate was used.
OBJECTIVE: To evaluate the effectiveness of arterial infusion with methotrexate in this unusual nail bed cancer.
METHODS: Right brachial arterial catheterization and infusion with methotrexate (50 mg) were used every 24 hours together with simultaneous intramuscular injection of 6 mg of leucovorin every 6 hours for 10 days.
RESULTS: At 4 years, 8 months after therapy, the patient was in sustained complete remission with a functionally normal right thumb.
CONCLUSION: This case study suggests that intra-arterial infusion chemotherapy is a simple and effective method for thumb subungual verrucous carcinoma with the unique advantage of preservation of morphology and functional conditions. It can be considered an effective treatment option.
OBJECTIVE: To evaluate the effectiveness of arterial infusion with methotrexate in this unusual nail bed cancer.
METHODS: Right brachial arterial catheterization and infusion with methotrexate (50 mg) were used every 24 hours together with simultaneous intramuscular injection of 6 mg of leucovorin every 6 hours for 10 days.
RESULTS: At 4 years, 8 months after therapy, the patient was in sustained complete remission with a functionally normal right thumb.
CONCLUSION: This case study suggests that intra-arterial infusion chemotherapy is a simple and effective method for thumb subungual verrucous carcinoma with the unique advantage of preservation of morphology and functional conditions. It can be considered an effective treatment option.