Cardiovascular diabetology · 2012
Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: a 3-dimensional cardiac computed tomography imaging study in Japanese subjects.
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Dagvasumberel Munkhbaatar, Shimabukuro Michio, Nishiuchi Takeshi, Ueno Junji, Takao Shoichiro, Fukuda Daiju, Hirata Yoichiro, Kurobe Hirotsugu, Soeki Takeshi, Iwase Takashi, Kusunose Kenya, Niki Toshiyuki, Yamaguchi Koji, Taketani Yoshio, Yagi Shusuke, Tomita Noriko, Yamada Hirotsugu, Wakatsuki Tetsuzo, Harada Masafumi, Kitagawa Tetsuya, Sata Masataka
Аннотация
BACKGROUND: Growing evidence suggests that epicardial adipose tissue (EAT) may contribute to the development of coronary artery disease (CAD). In this study, we explored gender disparities in EAT volume (EATV) and its impact on coronary atherosclerosis.
METHODS: The study population consisted of 90 consecutive subjects (age: 63 ± 12 years; men: 47, women: 43) who underwent 256-slice multi-detector computed tomography (MDCT) coronary angiography. EATV was measured as the sum of cross-sectional epicardial fat area on CT images, from the lower surface of the left pulmonary artery origin to the apex. Subjects were segregated into the CAD group (coronary luminal narrowing > 50%) and non-CAD group.
RESULTS: EATV/body surface area (BSA) was higher among men in the CAD group than in the non-CAD group (62 ± 13 vs. 33 ± 10 cm3/m2, p < 0.0001), but did not differ significantly among women in the 2 groups (49 ± 18 vs. 42 ± 9 cm3/m2, not significant). Multivariate logistic analysis showed that EATV/BSA was the single predictor for >50% coronary luminal narrowing in men (p < 0.0001). Predictors excluded were age, body mass index, hypertension, diabetes mellitus, and hyperlipidemia.
CONCLUSIONS: Increased EATV is strongly associated with coronary atherosclerosis in men.
METHODS: The study population consisted of 90 consecutive subjects (age: 63 ± 12 years; men: 47, women: 43) who underwent 256-slice multi-detector computed tomography (MDCT) coronary angiography. EATV was measured as the sum of cross-sectional epicardial fat area on CT images, from the lower surface of the left pulmonary artery origin to the apex. Subjects were segregated into the CAD group (coronary luminal narrowing > 50%) and non-CAD group.
RESULTS: EATV/body surface area (BSA) was higher among men in the CAD group than in the non-CAD group (62 ± 13 vs. 33 ± 10 cm3/m2, p < 0.0001), but did not differ significantly among women in the 2 groups (49 ± 18 vs. 42 ± 9 cm3/m2, not significant). Multivariate logistic analysis showed that EATV/BSA was the single predictor for >50% coronary luminal narrowing in men (p < 0.0001). Predictors excluded were age, body mass index, hypertension, diabetes mellitus, and hyperlipidemia.
CONCLUSIONS: Increased EATV is strongly associated with coronary atherosclerosis in men.
Предметные рубрики MeSH
Adipose TissueAge FactorsAgedAsian PeopleBody Surface AreaChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary StenosisFemaleHealth Status DisparitiesHumansJapanLogistic ModelsMaleMiddle AgedMultidetector Computed TomographyMultivariate AnalysisPericardiumPredictive Value of TestsRisk AssessmentRisk FactorsSeverity of Illness IndexSex Factors