Медицинская библиотека · Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih · 2001

The pathogenesis of experimental model of mitochondrial myopathy induced by germanium dioxide.

Li X, Gao F, Chen Q

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

OBJECTIVE

The purpose of the study was to build up an animal model of mitochondrial myopathy in order to analyse the pathogenesis of the disease.

METHODS

The skeletal muscles from Wistar rats treated with germanium dioxide for 24 weeks were analysed by histopathologic and electron-microscopic studies. A quantitative analysis was carried out in mitochondrial DNAs of these samples. The biological function of the model was determined.

RESULTS

An animal model of mitochondrial myopathy was built up, in which oxygen free radicals were increased and mitochondrial DNA copies were decreased contrasted with controls.

CONCLUSION

It suggested that environmental toxin may play a role in the pathogenesis of mitochondrial myopathy. The increase of oxygen free radicals is an important link causing the disease.

Для цитирования: Li X, Gao F, Chen Q. The pathogenesis of experimental model of mitochondrial myopathy induced by germanium dioxide.. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. 2001.

Предметные рубрики MeSH

Animals DNA, Mitochondrial Disease Models, Animal Germanium Male Mitochondria, Muscle Mitochondrial Myopathies Rats Rats, Wistar Reactive Oxygen Species

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