Phytomedicine : international journal of phytotherapy and phytopharmacology · 2024
Asiaticoside alleviated NAFLD by activating Nrf2 and inhibiting the NF-κB pathway.
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Wei Yunfei, Zhang Yibo, Zhan Baihe, Wang Yajie, Cheng Jiaqi, Yu Hao, Lv Mengfan, Zhang Yanmin, Zhai Yaxin, Guan Yuan, Feng Haihua
Аннотация
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a globally prevalent clinical problem of chronic liver disorder whose main pathogenic mechanisms are hepatic lipid accumulation, oxidative stress, and inflammatory reactions. Asiaticoside (Asi) is a compound derived from Centella asiatica, possesses antioxidant, antiphlogistic, antifibrotic, as well as wound healing properties.
PURPOSE: The aim of this study was to investigate the effects of Asi on NAFLD and its potential mechanisms.
STUDY DESIGN: Two versions of experimental models were constructed using free fatty acids (FFAs)-stimulated HepG2 cells along with high-fat diet (HFD)-incited NAFLD in mice.
METHODS: The pivotal action of Nrf2 was then explored using Ml-385 or Nrf2-/- mice.
RESULTS: The results indicated that Asi activated the Nrf2 to alleviate oxidative stress, inhibited the NF-κB to reduce the inflammatory response, and notably decreased lipid droplets and alleviated steatosis.
CONCLUSION: In conclusion, Asi demonstrates a potential to activate Nrf2 as well as inhibit the NF-κB pathway, there alleviate NAFLD.
PURPOSE: The aim of this study was to investigate the effects of Asi on NAFLD and its potential mechanisms.
STUDY DESIGN: Two versions of experimental models were constructed using free fatty acids (FFAs)-stimulated HepG2 cells along with high-fat diet (HFD)-incited NAFLD in mice.
METHODS: The pivotal action of Nrf2 was then explored using Ml-385 or Nrf2-/- mice.
RESULTS: The results indicated that Asi activated the Nrf2 to alleviate oxidative stress, inhibited the NF-κB to reduce the inflammatory response, and notably decreased lipid droplets and alleviated steatosis.
CONCLUSION: In conclusion, Asi demonstrates a potential to activate Nrf2 as well as inhibit the NF-κB pathway, there alleviate NAFLD.