Deutsche medizinische Wochenschrift (1946) · 2015
[77-year-old female with hyponatremia, pruritus and papulous exanthema].
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Brock Judith, Karrasch Thomas, Roller Fritz Christian, Steiner Dagmar, Nilles Martin, Blau Wolfgang, Gattenlöhner Stefan, Schäffler Andreas
Аннотация
HISTORY AND CLINICAL FINDINGS: A 77 year old female patient was admitted for the evaluation of hyponatremia and a generalized papulous exanthema with severe pruritus.
INVESTIGATIONS AND DIAGNOSIS: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) could be diagnosed as cause for hyponatremia. Biopsy of a soft tissue tumor revealed a T-cell lymphoma with widespread skelettal dissemination.
TREATMENT AND COURSE: Chemotherapy caused a rapid response and improvement of general well-being. SIADH could be controlled by the specific vasopressin-2-receptor antagonist tolvaptan.
CONCLUSIONS: In this patient, both the papulous exanthema and the SIADH are regarded as T-cell-lymphoma-associated paraneoplastic syndromes.
INVESTIGATIONS AND DIAGNOSIS: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) could be diagnosed as cause for hyponatremia. Biopsy of a soft tissue tumor revealed a T-cell lymphoma with widespread skelettal dissemination.
TREATMENT AND COURSE: Chemotherapy caused a rapid response and improvement of general well-being. SIADH could be controlled by the specific vasopressin-2-receptor antagonist tolvaptan.
CONCLUSIONS: In this patient, both the papulous exanthema and the SIADH are regarded as T-cell-lymphoma-associated paraneoplastic syndromes.
Предметные рубрики MeSH
AgedAntineoplastic Combined Chemotherapy ProtocolsBenzazepinesDiagnosis, DifferentialDisease ProgressionExanthemaFemaleHumansHyponatremiaInappropriate ADH SyndromeLymphoma, T-Cell, CutaneousMultimodal ImagingParaneoplastic SyndromesPositron-Emission TomographyPruritusTolvaptanTomography, X-Ray Computed